Insulin and non-esterified fatty acids. Acute regulators of lipogenesis in perfused rat liver
نویسندگان
چکیده
منابع مشابه
-linolenic acids in perfused rat liver
Trans polyunsaturated fatty acids are produced during heat treatment of oils, such as deodorization and frying. The detailed metabolic pathways of these trans isomers are not fully understood. In the present work, the desaturation and chain elongation of [114 C]linoleic acid, 9 cis ,12 trans -18:2, 9 trans ,12 cis -18:2, a -linolenic acid, 9 cis , 12 cis ,15 trans -18:3 and 9 trans ,12 cis ,15 ...
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Dyslipidaemia, with elevations of circulating triacylglycerols (triglycerides) and non-esterified (free) fatty acids, and hyperinsulinaemia are often found in the same subjects, the so-called 'insulin resistance syndrome'. The present study aims to investigate how elevated levels of non-esterified fatty acids, hyperinsulinaemia and the combination of these factors affects endothelium-dependent ...
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Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملNon-esterified fatty acids impair endothelium-dependent vasodilation in rat mesenteric resistance vessels.
Elevated circulating levels of NEFAs (non-esterified fatty acids) are associated with states of insulin resistance and increased risk of vascular disease. Previous animal and human studies have demonstrated NEFA-induced endothelial dysfunction of large conduit arteries, reversible by the antioxidant ascorbic acid. We therefore investigated the effect of NEFAs on carbachol-induced endothelium-de...
متن کاملSex differences in hepatic uptake of long chain fatty acids in single-pass perfused rat liver.
The primary determinants of hepatic uptake of long chain fatty acids have been considered to be the plasma concentrations of fatty acid and albumin, with little or no intrinsic control by the hepatocyte itself. However, recent studies of liver cell suspensions have shown that in immature, adult, castrated, and hormone-treated rats, sex steroids exert striking effects on [(14)C]oleate uptake and...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0306-3283
DOI: 10.1042/bj2040433